As a global company with operations across Asia, Europe, and North America, WuXi AppTec provides a broad portfolio of R&D and manufacturing services that enable global pharmaceutical and healthcare industry to advance discoveries and deliver groundbreaking treatments to patients. Through its unique business models, WuXi AppTec’s integrated, end-to-end services include chemistry drug CRDMO (Contract Research, Development and Manufacturing Organization), biology discovery, preclinical testing and clinical research services, cell and gene therapies CTDMO (Contract Testing, Development and Manufacturing Organization), helping customers improve the productivity of advancing healthcare products through cost-effective and efficient solutions.

Job Location: Shanghai, China

• Lead a multifunctional team with a focus on the discovery of oligonucleotide drugs.
• Design, execute, and evaluate strategies of an oligonucleotide biology platform.
• Develop and enhance the oligonucleotide drug discovery platform and capability.
• Lead the team to resolve scientific and technical challenges.
• Source and manage relationships, and evaluate the feasibility and effectiveness of outsource providers and collaborators.
• Lead team personnel to achieve the objectives and to develop the capabilities.
• Strive to enhance team’s performance through effective and efficient management of resources.
• Advice and develop BD strategies by working with the supervisor and BD teams.
• Document scientific findings and write manuscripts and patents.

• Ph.D. in biology or a relevant major with >6+ years of working experience in oligonucleotide drug discovery or related researches in industrial or academic institutes. Experience in siRNA or ASO focused industrial company is preferred.
• Comprehensive knowledge of the discovery of various oligonucleotide drugs, especially ASO and siRNA, including drug design, chemical modification, delivery system, in vitro and in vivo evaluations, ADME/PK and toxicology, bioanalysis, bioinformatics for oligonucleotide agents.
• Familiar with the discovery and development of therapeutic oligonucleotides, especially ASO and siRNA agents.
• Hands-on experience in cellular and molecular biology and immunology, etc.
• A proven track record of scientific publications on ASO, siRNA, mRNA or other RNA drug discovery.
• High motivation to embrace new technologies and tools.
• Proven capability and experience in managing and leading high performance teams
• Demonstrated strong communication skills, high ability to build personal rapport with all stakeholders.
• Fluency in reading, writing and speaking Mandarin Chinese and English.