WuXi AppTec

  • Scientist - Molecular Biology / Genetic Stability

    Job Locations US-PA-Philadelphia
    Job ID
  • Overview

    Independent Sequencing Scientist who demonstrates advanced technical sequencing expertise, particularly Next Generation Sequencing (NGS), and significantly contributes significantly to sequencing operations in the Molecular Biology Testing lab.  Demonstrates strong oral and written communication skills and actively contributes to staff training.  Generates GMP, R&D and validation reports, GMP documents and GMP Batch Records in role as Sequencing Study Director/ Technical Reviewer. Demonstrates strong supervisory skills and contributes to the achievement of company and departmental goals and objectives.  Performs and directs assays according to and in compliance with current Good Manufacturing Practice (cGMP), Code of Federal Regulations (CFR) and/or Points to Consider (PTC) guidelines and Standard Operating Procedures (SOPs).


    • Demonstrates innovative and independent scientific technical expertise in sequencing.
    • Conducts and directs assays and lab procedures according to and in compliance with GLP, cGMP, CFR and/or PTC guidelines and SOPs.
    • Accurately completes batch records and other required documentation according to and in compliance with GLP, cGMP, CFR and/or PTC guidelines and SOPs.
    • Works with Department Scheduling Supervisor to coordinate sequencing assays.
    • Contributes independently to overall scientific rigor of laboratory operations through objective laboratory investigation.
    • As assigned by Management, supervises personnel and assumes all associated responsibilities.
    • As assigned by Management, acts as Study Director, Area Manager, or Principal Investigator for assays, conducts critical review of results and data, and assumes all associated responsibilities. 
    • Demonstrates proficiency in scientific theory and rigorous practical application in the completion of lab procedures.
    • Designs and independently conducts scientific development projects from inception to completion.
    • Initiates, prepares and revises technical documents and reports.
    • Effectively communicates and defends science through written and verbal communication.
    • Maintains laboratory notebook and reviews and signs lab notebooks (when appropriate).
    • Follows all general and laboratory SOPs.
    • Performs assays using appropriate sequencing laboratory techniques.
    • Reports observations of ongoing tests to Study Directors, Area Manager or Principal Investigator.
    • Communicates with supervisor and other colleagues re: daily lab activities, instrument and assay issues and test method performance.
    • Provides training on areas of technical expertise and compliance issues relevant to the lab setting and trains new personnel in lab procedures.
    • Effectively interacts with clients as required.
    • Completes all requisite training (i.e. Bloodborne Pathogen, Quality Assurance, safety, etc.).
    • Ability to work in a team environment and independently as required
    • Contributes to the overall operations and to the achievement of departmental goals
    • Perform job specific tasks in compliance with applicable Regulations, International Standards, and WuXi AppTec Policies and Standard Operating Procedures.
    • Thorough understanding of Good Manufacturing Practices (GMP) and Good Documentation Practices (GDP)
    • Performs other duties as assigned.


    Experience / Education   

    • BS/MS/PhD
    • Minimum of one year experience
    • Specialized hands on training and experience with Next Generation and Sanger Sequencing is required.
    • Advanced knowledge of sequencing chemistries and methods is required.
    • Experience designing and troubleshooting sequencing assays and the ability to explain unexpected results and solve technical issues is required


    Knowledge / Skills / Abilities:

    • Ability to work in a fast paced laboratory with fluctuating workload and handle problems of a more difficult nature is required as is the ability to work successfully under limited supervision.
    • Experience evaluating and assembling sequencing data
    • Specialized training in laboratory techniques used in assigned laboratory is required.
    • Knowledge of GLP and cGMP guidelines is preferred.
    • Ability to use judgment as dictated by complexity of situation.
    • Ability to work under limited supervision and to handle problems of a more difficult nature.
    • Ability to accomplish the described duties through the use of appropriate laboratory equipment (i.e. biohazard hood, centrifuge, incubator, and autoclave) and computer equipment and software. (i.e. Microsoft Word, Outlook).
    • Ability to accurately and reproducibly perform arithmetic calculations including fractions, decimals and percentages and basic algebraic and geometric calculations.
    • Able to communication with internal and external clients.

    Equal Opportunity Employer Minorities/Women/Veterans/Disabled  


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