WuXi AppTec

Senior Scientist

Job Locations US-CA-San Diego
Job ID
2020-6428

Overview

The candidate for this position will be responsible for performance of experiments to support in vitro screening and/or evaluation of small molecule and biologics drug candidates. The position requires experience and exceptional skills in Molecular biology, Cell Biology, and Biochemistry techniques. Prior experience with medium- to high-throughput screening, high-content imaging, liquid handlers, fluorescence and luminescence-based assay platforms is highly desirable. Candidates with virology research experience will be given preference.

Responsibilities

  • Provide operational support for the Department of Infectious Disease activities including:

-Generation and maintenance of virus and cell culture stocks.

-Designing and conducting experiments independently or with minimum supervision.

-Participation in general laboratory operations

-Operation and maintenance of laboratory equipment

-Keeping track of reagent inventory/ordering reagents when necessary

-General upkeep of the lab; maintenance of a clean and safe laboratory work environment per regulations and guidelines.

-Development of SOPs.

-Writing of proposals, and preparation of quotes for commercial contracts.

-Maintenance of accurate records of laboratory data

-Data analysis and interpretation; clear and concise presentation of data in internal and external meetings.

-Preparation of reports for internal team and external clients.

-Keeping current with relevant technical literature and regulatory requirements.

-Providing assistance in identification of new technology, assays, equipment, and other laboratory needs for the advancement of assigned projects.

-Coordination/collaboration with internal team and external clients.

-Timely completion of assigned projects.

-Providing assistance to the team leader in identification and implementation of new research avenues.

  • Maybe required to work Holidays and weekends
  • Contribution to the overall operations and to the achievement of departmental goals
  • Perform job specific tasks in compliance with applicable regulations, International Standards, and WuXi AppTec Policies and Standard Operating Procedures.
  • Other duties as assigned
  • May be required to assist in other departments

Qualifications

Experience / Education:    

  • Master’s Degree in Molecular Microbiology, Molecular Biology, Cell Biology or a related field and a minimum of 4+ years of relevant post-graduate experience (preferably in the industry environment) required; preference of a Ph.D. with 2+ years of industry experience.
  • Thorough knowledge of the principles of biological assay development, validation, quality assurance, and implementation in discovery research.
  • BSL-2 laboratory experience, and knowledge of laboratory biosafety regulations and guidelines.
  • Experience in development, optimization/validation, and implementation of drug screening assays in medium- to high-throughput format.
  • Experience with virus infectivity and quantitation assays, such as plaque assays/PRNTs, CPE assays, RT/qPCR, fluorescence-based focus forming assay, flow cytometry-based assays, ELISA, reporter gene assays, high-content imaging assays etc.
  • Experience with a variety of laboratory instruments such as liquid handlers, multi-label plate readers, qPCR instruments, flow cytometer, high-content imaging systems.
  • Experience culturing and maintaining a mammalian cell lines and primary cells
  • Experience culturing and manipulating DNA and RNA viruses, especially HIV, Influenza, RSV, HCV, and/or HBV will be a plus.
  • Experience with RNA virus reverse genetics/infectious clone production and manipulation is desirable.
  • Experience in virus-based gene transfer vectors is desirable.

Knowledge / Skills / Abilities:

  • Comprehensive knowledge of and skills in Molecular Biology, Cell Biology, and/or Biochemistry techniques.
  • Proficiency in oral & written communication skills in English
  • Proficiency in Microsoft (Excel, Word, Outlook), and statistics/graphing software for data analysis and presentation.

Physical Requirements:         

  • Must be able to work in an office environment with minimal noise conditions.
  • Must be able to work in Lab setting with exposure to Animals/biohazards / Chemicals (List specific Chemicals)
  • Must be able to wear appropriate PPE
  • Must be able to work in environment with variable noise levels
  • Ability to stand /Sit/walk for long periods of time
  • Ability to Lift 10 lbs routinely
  • Ability to crouch, bend, twist, and reach
  • Ability to push/pull 10 lbs routinely/ often / occasionally
  • Clarity of Vision
  • Ability to identify and distinguish colors
  • Must be able to perform activities with repetitive motions
  • Ability to climb Ladders / Stairs / Scaffolding
  • Ability to work in variable temperatures high to freezing
  • Inside/outside working conditions

An Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, or protected veteran status and will not be discriminated against on the basis of disability

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