WuXi AppTec

Scientist - Process Development, Cell Line Development

Job Locations US-PA-Philadelphia
Job ID


Independent scientist contributing to the development of viral constructs for both AAV and Lenti-viral Vector production in the field of Gene and Cell Therapy. This position will work with a team of scientists and technical specialists responsible
for process development, technology transfer and GMP manufacturing.


  • Designs and constructs viral plasmids for high titer AAV and Lenti-viral Vector production
  • Employs state-of-the-art methods at various stages of cell line development and independently generates stable AAV and Lenti-cell lines of high productivity and quality
  • Performs single cell cloning for virus production cell lines
  • Conducts molecular biology studies to construct or modify expression vectors, genetically characterize the cell lines, analyze for sequence variants, etc.
  • Designs and performs assays to characterize plasmids and cell lines
  • Conducts hands-on studies, and serves as a technical resource for staff and leverages expertise in laboratory technology as a functional resource/trainer
  • Authors documents for technical transfer and regulatory filings
  • Understands project timelines, milestones and deliverables.
  • Provides technical leadership to project teams within area of expertise and commits resources to execute specific project tasks
  • Contributes significantly and independently to project work, which may include multiple projects within functional area.
  • Plans and implements resolutions to technical problems/issues


  • Bachelor’s degree with major in Biological or Chemical Engineering, Biological Sciences, Immunology or other science-related field, with 4-6 years of relevant experience
  • Master degree with 2-4 years of relevant experience
  • PhD degree with 0-2 years of relevant experience


Knowledge / Skills / Abilities:

  • Experience in viral construct development, suspension cell culture, recombinant protein expression, cell line development.
  • Experience of molecular and cellular biology in a bioprocess development environment is essential
  • Experience in genome engineering technologies such as CRISPR is a plus
  • Proficient in viral plasmids cloning, suspension culturing, stable cell line development and associated molecular and cellular techniques
  • Experience of Baculovirus work plus
  • Experience and knowledge in the following aspects of viral constructs design, cell line development using suspension cells are highly preferred.
  • Use of modern technologies for plasmids development; enrichment of recombinant cells and cell
    cloning; clonality determination; clone screening using automated systems; fedbatch culture in Ambr and bioreactors; and molecular analyses of recombinant cell lines
  • Knowledge of regulatory requirements of the production cell lines for biotherapeutics
  • Knowledge of emerging technologies, and motivation to continually improve processes


Our Values:

Integrity & Dedication, Working Together & Sharing Success; Do the Right Thing & Do it Right.


Our greatest asset is our people, WuXi is dedicated to providing opportunities for internal growth with direct access to a dedicated and accessible Human Resources team.


WuXi AppTec provides equal employment opportunity to all individuals regardless of their race, color, creed, religion, gender, age, sexual orientation, national origin, disability, veteran status, or any other characteristic protected by state, federal, or local law.


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